Haemoglobin(βK120C)–albumin trimer as an artificial O2carrier with sufficient haemoglobin allostery

Artificial self-sufficient P450 in reversed micelles.

Cytochrome P450s are heme-containing monooxygenases that require electron transfer proteins for their catalytic activities. They prefer hydrophobic compounds as substrates and it is, therefore, desirable to perform their reactions in non-aqueous media. Reversed micelles can stably encapsulate proteins in nano-scaled water pools in organic solvents. However, in the reversed micellar system, when...

Intrinsic disorder and allostery in an ensemble

Features as Sufficient Statistics

An image is often represented by a set of detected features. We get an enormous compression by representing images in this way. Furthermore, we get a representation which is little affected by small amounts of noise in the image. However, features are typically chosen in an ad hoc manner. \Ve show how a good set of features can be obtained using sufficient statistics. The idea of sparse data re...

Experiences with Artificial Intelligence as an Undergraduate Creative Capstone Course

This paper introduces a model called the “creative capstone” for teaching Artificial Intelligence at the undergraduate level. The model leverages AI’s image as a creative endeavor, while mitigating its image as a less practical option. The course was implemented and taught five times, and the resulting experiences are described. Specific techniques for helping ensure the success of the course a...

An ensemble view of thrombin allostery.

Thrombin is the central protease of the coagulation cascade. Its activity is tightly regulated to ensure rapid blood clotting while preventing uncontrolled thrombosis. Thrombin interacts with multiple substrates and cofactors and is critically involved in both pro- and anticoagulant pathways of the coagulation network. Its allosteric regulation, especially by the monovalent cation Na(+), has be...